serum smas

Useful For

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Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with chronic liver disease in whom the diagnosis of chronic active autoimmune hepatitis is suspected

Reflex Tests

Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Testing Algorithm

Delineates situations when tests are added to tát the initial order. This includes reflex and additional tests.

If smooth muscle antibody (SMA) screen is positive then the SMA titer will be performed at an additional charge.

Method Name

A short mô tả tìm kiếm of the method used to tát perform the test

Indirect Immunofluorescence

NY State Available

Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name

Lists a shorter or abbreviated version of the Published Name for a test

Smooth Muscle Ab Screen, S

Aliases

Lists additional common names for a test, as an aid in searching

Testing Algorithm

Delineates situations when tests are added to tát the initial order. This includes reflex and additional tests.

If smooth muscle antibody (SMA) screen is positive then the SMA titer will be performed at an additional charge.

Specimen Type

Describes the specimen type validated for testing

Serum

Specimen Required

Defines the optimal specimen required to tát perform the test and the preferred volume to tát complete testing

Forms

Specimen Minimum Volume

Defines the amount of sample necessary to tát provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

0.4 mL

Reject Due To

Identifies specimen types and conditions that may cause the specimen to tát be rejected

Specimen Stability Information

Provides a mô tả tìm kiếm of the temperatures required to tát transport a specimen to tát the performing laboratory, alternate acceptable temperatures are also included

Useful For

Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with chronic liver disease in whom the diagnosis of chronic active autoimmune hepatitis is suspected

Testing Algorithm

Delineates situations when tests are added to tát the initial order. This includes reflex and additional tests.

If smooth muscle antibody (SMA) screen is positive then the SMA titer will be performed at an additional charge.

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Clinical Information

Discusses physiology, pathophysiology, and general clinical aspects, as they relate to tát a laboratory test

Autoimmune hepatitis (AIH) is caused by chronic inflammation within the liver, resulting in damage to tát the hepatocytes.(1) Initially, patients with AIH may be clinically asymptomatic, usually identified only through an incidental finding of abnormal liver function tests. At a more advanced stage, patients may manifest with symptoms such as jaundice, pruritus, or ascites, which are secondary to tát the more extensive liver damage. As implied by the name, AIH has many characteristics of an autoimmune disease, including female predominance, hypergammaglobulinemia, association with specific HLA alleles, responsiveness to tát immunosuppression, and the presence of autoantibodies. There are several autoantibodies associated with AIH, although the most common are smooth muscle antibodies (SMA). SMA are generally identified by indirect immunofluorescence using a smooth muscle substrate. The antigen specificity of SMA in the context of AIH has been identified as filamentous-actin (F-actin).(2) Because the clinical symptoms of AIH are nonspecific, being found in a variety of liver diseases (drug/alcohol-associated hepatitis, viral hepatitis, primary sclerosing cholangitis, etc), the diagnosis can be challenging. A mix of diagnostic criteria for AIH has been published and includes the presence of various autoantibodies, elevated total IgG, evidence of hepatitis on liver histology, and absence of viral markers.(3) The combination of autoantibody serology, specifically SMA and anti-F-actin antibodies with liver histology and thorough clinical evaluation are useful in the evaluation of patients with suspected autoimmune hepatitis.

Reference Values

Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Interpretation

Provides information to tát assist in interpretation of the test results

Cautions

Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Clinical Reference

Recommendations for in-depth reading of a clinical nature

Method Description

Describes how the test is performed and provides a method-specific reference

The patient's serum in 1:20 and 1:40 (initial screening) dilutions is added to tát fresh tissue from mouse stomach/kidney and incubated; fluorescein-conjugated antiglobulin is then added. The slides are read with a fluorescence microscope.(Package insert: Kallestad Mouse Stomach/Kidney. Bio-Rad Laboratories, Inc; 01/2018)

PDF Report

Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed

Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to tát begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Saturday

Report Available

The interval of time (receipt of sample at Mayo Clinic Laboratories to tát results available) taking into trương mục standard setup days and weekends. The first day is the time that it typically takes for a result to tát be available. The last day is the time it might take, accounting for any necessary repeated testing.

2 to tát 4 days

Specimen Retention Time

Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

14 days

Performing Laboratory Location

Indicates the location of the laboratory that performs the test

Rochester

Fees

Several factors determine the fee charged to tát perform a test. Liên hệ your U.S. or International Regional Manager for information about establishing a fee schedule or to tát learn more about resources to tát optimize test selection.

Test Classification

Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that vì thế not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to tát determine correct CPT codes to tát use for billing.

CPT codes are provided by the performing laboratory.

86015

LOINC® Information

Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.